![]() ![]() Activity and specificity of TBK1 are defined by adaptor proteins these recruit TBK1 to microdomains on ubiquitinated Salmonella or mitochondria, thereby facilitating its local clustering and activation ( 18), where it in turn can phosphorylate autophagy receptors ( 15). TANK-binding kinase 1 (TBK1) phosphorylates OPTN on S177, thereby enhancing LC3-binding affinity and autophagic clearance of cytosolic Salmonella ( 15). The autophagy receptors optineurin (OPTN) and p62 are first activated by protein kinases to effectively target autophagic membranes or their polyUb cargo ( 15– 17). Thus, TBK1-mediated phosphorylation of autophagy receptors creates a signal amplification loop operating in selective autophagy of damaged mitochondria.Īutophagy receptors function as decoders for the various ubiquitin signals on cargoes, linking cargoes to autophagosomal membranes ( 4) however, the basis of their individual recruitment to cargo as well as their distinct and cooperative functions in cargo sequestration are still poorly understood. Moreover, phosphorylation of OPTN on S473 enables binding to pS65 Ub chains and is also implicated in PINK1-driven and Parkin-independent mitophagy. In combination with phosphorylation of S177 and S513, this posttranslational modification promotes recruitment and retention of OPTN/TBK1 on ubiquitinated, damaged mitochondria. ![]() TBK1 in turn phosphorylates OPTN’s UBAN domain at S473, thereby expanding the binding capacity of OPTN to diverse Ub chains. Constitutive interaction of TBK1 with OPTN and the ability of OPTN to bind to ubiquitin chains are essential for TBK1 recruitment and kinase activation on mitochondria. By using quantitative proteomics, we show that Tank-binding kinase 1 (TBK1) phosphorylates all four receptors on several autophagy-relevant sites, including the ubiquitin- and LC3-binding domains of OPTN and p62/SQSTM1 as well as the SKICH domains of NDP52 and TAX1BP1. Selective autophagy of damaged mitochondria requires autophagy receptors optineurin (OPTN), NDP52 (CALCOCO2), TAX1BP1, and p62 (SQSTM1) linking ubiquitinated cargo to autophagic membranes. ![]()
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![]() ![]() THat was just a wartime expedient on some No. If it's from the 1950s, it's not a MK I, anyway, and the two position flip sight is NOT proper for it. Not to be hard, just my 0.02 and worth every pennyĭoes your rifle have the letters FTR on it? Means Factory Thorough Repair. It will go to one of my nephews, eventually. As an example that is a dream to shoot, it is the one I was waiting for for several decades. ![]() Was it assembled using left over parts from past production, were the "upgrades" done when the arm was sent in for armory servicing? No way to know. It has the superior milled rear micrometer sight ( instead of the proper for model flip up sight ), milled front sight guard (instead of the proper for model stamped version ) and a clearly used in the field brass buttplate with trapdoor, instead of the proper steel late production item. I have one of these, though of early 1950's vintage bought at a gun show with no pedigree. Yes, commercial ammo form PPU and recently, Wolf ( Military Classic ) is available at "popular" prices, hunting ammo is priced up with everyone else's. ![]() Perhaps I'm being a nostalgic, maudlin, soon to be Geezer, but I cannot fathom how such a tie to family history should be simply sold off, even if you have NO interest in shooting it. What I would do to see them one more time. But then again maybe others did not care their papa's as I did mine. I will never be so broke that I need to sell it. You are in possession of your grandfathers rifle and the first thought is how much can I sell it for? I would rather be drug naked through a cactus patch than give up my grandfathers gun. 4 is a MK II from 1952 and my son has an unissued, new one from 1955. Opposing Broad Arrows indicate that the rifle was sold from Stores and became the private properrty of an officer, allowed to buy from the govt. ownership, not that the rifle was exported. I don't own "truck guns." Others like the heavily used and uncared for look.Ī lot of these rifles were sold by the Crown as scrap metal, not as firearms. Unless you're not showing us something that might affect value, that's my best guess.ĭid you check the rear face of the bolt handle for numbers? The photos are poor, but good enough tp tell that the rifle is at best in just average condition, with numerous small dents and the wood looks dried out and considerable bluing is missing from the magazine. Should tell the manufacturer there, like Fazakerly, and the model of rifle, like No. You ignored the markings that should be on the left side of the action. ![]() ![]() ![]() In 26 trials studying the care of more than 3000 patients, stimulation of the PC 6 acupuncture point was superior to sham acupuncture for the treatment of nausea and vomiting in both adults and children. These results have been the most consistent in its use for postoperative nausea and vomiting. ![]() PC 6 acupuncture point stimulation can be superior to antiemetic medication for nausea and vomiting. 33 However, in RCTs conducted by Yentis and colleagues 34 and Lewis and associates, 35 acupuncture and acupressure were found to be ineffective in preventing nausea and vomiting associated with strabismus repair. 32 A doubleblind, randomized, placebo-controlled study revealed that hand acupressure is an effective method for reducing postoperative vomiting in children after strabismus repair. 31 Acupuncture is as effective as droperidol in controlling early postoperative nausea and vomiting in children. This study demonstrated that the efficacy of acupuncture for postoperative nausea and vomiting prevention is similar to commonly used pharmacotherapies. 30 An RCT of pediatric patients that underwent tonsillectomy using electroacupuncture showed a significant reduction in the occurrence of nausea when compared with the sham and control groups. ![]() A systematic review revealed beneficial results in 27 out of 33 RCTs of acupuncture, acupressure, or both, on the treatment of nausea and vomiting. Stimulation of the PC 6 ( Nei guan) acupuncture point is also used to treat nausea and vomiting caused by sea sickness or pregnancy or to treat side effects of surgery or chemotherapy. Yuan-Chi Lin, in Raj's Practical Management of Pain (Fourth Edition), 2008 Nausea and VomitingĪcupuncture using acupuncture needles, electrical apparatus, pressure, or magnets is commonly used for the management of nausea and vomiting caused by surgery or chemotherapy. ![]() ![]() A general thumb rule is that one should position the clock so that the time can be visible from any part of the room. Having it placed centrally in a room or a corner can change the visual appeal of a room. Many prefer a clock mounted on a wall while some may want it leaning against the wall. ![]() Where the clock is finally placed is perhaps one of the most important things to consider. ![]() While a vintage wall clock will look great in a formal set-up like a study, a modern wall clock may be more apt for a living room or bedroom with stylish furniture and trendy colours. The material and colour of the wall clock should also blend in well with the design scheme. A vintage wall clock for a home may be perfect for a stylish living room while a table clock is likely to suffice for the bedroom.Ī wall clock should appropriately match the furniture and the décor of the room where you intend to place it. A clock should attract attention for its design and finish rather than for being too big or too small for the room where its placed. The size and type of the clock you buy are directly impacted by the size of the room where you will place it. Here are some of the more important considerations that you should keep in mind. One needs to put in a lot of time and effort before deciding which wall clock to buy. FACTORS TO KEEP IN MIND WHILE BUYING CLOCKS Like other home décor items, the design and style of a wall clock also give you an insight into the owners and what makes them tick or tock.ĭespite what many say, wall clocks are never going to go out of style and will always be a part of home décor. Having a vintage wall clock or a modern contemporary one can make your home look visually appealing. Having a wall clock for home also helps improve our time management skills, ensuring punctuality for important meetings or events, in order to not have anybody waiting.īesides this functional aspect, having a wall clock can really amplify the style quotient in your home. From a functional point of view, it helps us keep track of time for our daily tasks, errands, TV programs and our meals. Having a wall clock for home has multiple benefits. Despite the advent of smartphones and our tendency to check the time on our phones, clocks still occupy the prime spot in any home. The invention of clocks has made it easier for everyone to read the time. In early civilizations, human beings would look at the position of the sun and shadow to decipher time and days. ![]() ![]() Clocks have been an integral part of our homes for centuries now. ![]() ![]() And when you click on the file or icon it will count as a download. Note that there is a limit to the number of files you can download. If you have some stuff that not is listed here you can donate this by contact mods.dk. In this page you find schematic, users and instructions manuals, service manuals, technical supplement, leaf leads and other good stuff. Mods.dk -> Instruction, users and service manuals for _other ![]() ![]() Jace to arrive and activate the prince's pod. Vertigo leaves to report back to his superior, leaving Dr. Ecks shows the metahuman trafficking lab to a horrified Brion before Vertigo knocks him out and has him thrown into a pod. Superboy and Black Lightning find the captive meta-children, but are attacked by Count Vertigo and Plasmus.ĭespite sustaining injuries, Black Lightning manages to escape while Superboy is captured. Prince Brion is at odds with his brother over their uncle becoming regent and plans to activate his meta-gene to save his country with the help of geneticist Dr. Nightwing and Tigress go undercover at the king's pre-coronation party while Superboy and Black Lightning go underground to find the labs. Baron DeLamb declares that vigilante heroes are unwelcome in Markovia, just as Dick's team arrives in the country to investigate the metahuman trafficking syndicate, 'Bedlam'. The Justice League announces the resignation of several members in response to the U.N.'s restrictions. Despite these, he ultimately agrees to join. Dick also asks Black Lightning to join, but Jefferson is hesitant due to his guilt over his actions and fluctuating abilities. Nightwing and Oracle discover that the traffickers' labs are using a tar-like substance from Markovia and recruit Superboy and Tigress to help infiltrate the country. ![]() ![]() Jace that he tested positive for the meta-gene. His fraternal twin brother, Brion, wants to form a team that can continue his parents' mission and learns from royal physician Dr. Black Lightning also resigns, but only to recover from an incident on Rann weeks earlier.ĭays later, King Viktor and Queen Ilona of Markovia announce their plans to help end metahuman trafficking, as their daughter Princess Tara was abducted two years ago for her own meta-gene, but are assassinated by a metahuman placing Markovia under martial law with Queen Ilona's brother, Baron DeLamb, serving as Regent until the eldest, Crown Prince Gregor, turns 18. Recognizing the restrictions, Batman, Green Arrow, their respective proteges on the Team, among others resign in a pre-planned move to operate as vigilantes again. ![]() Secretary General Lex Luthor hindering their efforts. Two years after the Reach's defeat, metahuman trafficking has reached galactic levels, but the Justice League is unable to intercede due to the U.N. ![]() ![]() ![]() You are simply expressing your thoughts and feelings as they come to you, without inhibition, without shame. That means everything you say and do must be done without any ulterior motive. Vulnerability requires honesty, and honesty only works if it’s given unconditionally, with no strings attached. ![]() The more nervous it makes you, the better, because it means you’re being authentic and making yourself vulnerable. You say it because you mean it and mean it because you say it. So the catch is that everything you say must be as authentic as possible.A non-needy man is comfortable showing his flaws because he’s more comfortable with how he feels about himself than how others feel about him.A man who’s able to make himself vulnerable is saying to the world, "Screw the repercussions this is who I am, and I refuse to be anyone else." He’s saying he is non-needy and high status. Vulnerability represents a form of power, a deep and subtle form of power.Not just emotional vulnerability (although we’ll get to that), but physical vulnerability, social vulnerability. I want you to think of vulnerability in a more broad way.Take care of yourself and those who are important to you. The only real dating advice is self-improvement.Seduction is the process by which a man induces a woman to become as invested in him as he is in her.A man's attractiveness is inversely proportional to how needy he is.Notes Part I: Reality Chapter 1: Non-Neediness ![]() |
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